Yearly Archives: 2010

Scripps Florida builds SE biotech

The Daily Business Review credits Scripps Florida for its impact on biotech innovation. (Subscription required)

Scripps Florida – the first and sole satellite of the Scripps Research Institute, is one of only three national translational research high-throughput screening centers approved by the NIH and received the first NIH drug development grant.

Its presence has helped South Florida attract other impressive research organizations: the Max Planck Institute (Jupiter), Torrey Pines Institute for Molecular Studies and the Vaccine and Gene Therapy Instititute (Port St. Lucie), Sandford-Burnham Medical Research Institute (Orlando), and The University of Miami’s Life Science Park.

While biotech research is becoming more and more the province of research centers, the resulting technology spin-offs do tend to cluster around those research centers. Mark Mirkin of Carlton Fields writes:

For better or worse, biotech innovation has largely been abandoned as a primary pursuit by pharmaceutical companies, becoming the pursuit of universities and research institutes, leaving pharma to focus on applied research. (Although) it is difficult to calculate with precision a rate of return on an investment in basic research because of the lenghty time period between discovery and application, it is hard not to notice that hundreds of biotech companies have arisen in the San Diego area, home of Scripps, and hundreds of others have arisen in Germany’s Bavaria region, home of Max Planck.”

Upcoming Florida Early Stage Conference

This October 5, Florida entrepreneurs will showcase their high-growth emerging companies at the 2010 Early Stage Venture Capital Conference, hosted by the Florida Venture Forum at the Omni Orlando Resort at ChampionsGate.

Venture capitalists, angel investors, private equity investors and service providers from Florida and around the nation will gather to support and encourage early stage investing in Florida – a vital component of our flourishing venture ecosystem and economy.

Presenter application submissions will be accepted through August 31, and can be completed online here.  All other attendees can register here.

Capital gains stealing your equity?

Taxes are a major determinant of the returns on any investment, and especially for an entrepreneur whose company is often his or her primary vehicle of wealth creation.

Two significant changes to the tax code are likely to occur in the next few years, both of which will directly affect entrepreneurs:

  1. The tax cuts passed by Congress in 2001 and 2003 expire at the end of 2010.
  2. The recently enacted health care reform initiates additional taxes on all investment gains starting in 2013, including the extension of Medicare taxes to all investment gains – effectively adding an additional 3.8% to the long term capital gains tax rate.

We have published a brief white paper which highlights how an entrepreneur could take taxes into consideration when contemplating a capital raise, and how he or she might maximize the value of the after-tax proceeds from a minority recapitalization.

No entrepreneur should make significant changes in the long term plans for his or her business based solely on likely changes in the tax code. However, if you or your shareholders are currently considering a capital raise and/or would like to consider realizing some liquidity on part of your investment over the next 12 months, it may well make sense to accelerate the timing to beat the December 31, 2010 and/or 2013 deadlines.

UPDATE 7/23/10:

A recent editorial in Investors Business Daily entitled The Tax Tsunami On The Horizon maintains that there are three upcoming “waves” of taxes, including those we mention above: (1) the expiration of various tax cuts enacted last decade, (2) new taxes designed to pay for health care reform, and (3) the alternative minimum tax’s widening net, upcoming tax hikes on employers, and the loss of deductions for tuition.

Mr. Williams Goes to Washington

Rhys Williams is an old friend of BPV and both a successful biotech entrepreneur and a founding member and President of one of the largest and most successful statewide angel investing groups in Florida (New World Angels).  So we were delighted to hear that Rhys was recently invited by Senator George LeMieux (R-FL) to testify at theInnovation in America: Opportunities and Obstacleshearing before the U.S. Senate Committee Subcommittee on Competitiveness, Innovation, and Export Promotion.  Florida’s entrepreneurial community could not have asked for a better spokesman on issues of importance to early stage entrepreneurs in Florida and throughout the country.  And kudos to Senator LeMieux for inviting Rhys to speak.

If you want to watch Rhys’s testimony, it can be seen from minute markers 107:16 to 113:30 of the hearing’s webcast at the Senate Committee’s site; and his Q&A session (where he really shines in our opinion) runs from 125:44 to 128:44.  A transcript of his testimony is also available at the site for those who prefer some enjoyable reading without the interruptions.  In addition to making compelling points, Rhys does an excellent job dealing with the standard difficulties of that environment:  having your thunder stolen by earlier witnesses and getting squeezed for time at the end so the Senators get enough of their own “air time”.

For those who want the “Rhys’s Points for Dummies” summary, he offered six specific recommendations which, from the perspective of angel investors and early-stage entrepreneurs, would improve both innovation and the nation’s overall economic performance:

  1. FDA Reform. Fill vacancies more quickly, speed up regulatory review, and switch from the “zero defect” to the “calculated risk” model.  In recent years, high profile drug safety incidents have hamstrung regulators – costing years of product development time and burning up precious capital.
  2. Address the backlog of patents. The US Patent & Trademark Office has a backlog of up to 3.5 years – which lengthens time to market, increases legal costs and creates uncertainty.  In addition to working the backlog with additional resources, expedited reviews should be granted for strategic sectors and IP with greater risk of piracy.  Also push for reciprocity and enforcement of IP violations within foreign jurisdictions.
  3. Tax reform.  The current federal tax framework dampens innovation and competitiveness.  In addition to lowering certain rates tied to investment activity (capital gains, carried interest), we ought to create tax credits for: innovative companies, angel investors, and certain specific business activities (capital attracted, employment growth, capital expenditures, etc) in order to promote a true, sustainable “growth agenda.”
  4. Simplify federal and state securities regulations.  Early stage firms are forced to devote too much time and attention to regulations intended for much larger firms.
  5. Promote the “Entrepreneurial Ecosystem”.    Develop and integrate the local and regional infrastructure for the commercialization of R&D, the growth of private angel investor networks, and the provision of matching grants to qualified SBIR/STTR grant recipients.
  6. Preserve the missions of SBIR/STTR.  (Small Business Innovation Research and Small Business Technology Transfer)  Protect their funding from encroachment by larger firms.

Thank you to Rhys for traveling to D.C. on his own dime and making the case so succinctly.  Everyone involved in Florida’s early stage entrepreneurial culture would benefit from echoing these points to our state and national legislators and regulators as often as possible as we debate how to ignite renewed economic growth in America.

Encouraging Innovation

Some excellent advice on new technologies:  even when there is no immediately apparent benefit to your business, having employees dabble a bit with “the technology of the era” helps them imagine what might be technologically possible.

Dreaming big, innovating in processes/systems unrelated to the technology, spotting early trends for customers and vendors (or portfolio companies, present and future!) – these are the positive side effects from playing with not-yet-ready-for-our-business technologies.

Tom Glocer, CEO of Thomson Reuters, shares the story of giving his staff first-generation mp3 players (9 years ago) for Christmas and challenging them with a “Christmas assignment.”

Where America’s Money is Moving

Forbes analyzed IRS data to determine future “hot spots” for real estate and concluded what we already knew:  Americans prefer the good weather, low taxes, and favorable business climate offered by the Southeast.

The dominance of the list by Florida and Texas–the former has eight of the top 20 counties, the latter four– makes sense to Robert Shrum, manager of state affairs at the Tax Foundation in Washington, D.C., since neither state has an income tax. “If you’re a high-income earner, then that, from a tax perspective, is going to be a driving decider if you’re going to move to one of those two states,” Shrum says.

After accounting for property taxes, Shrum’s analysis shows that Texas has the fourth-lowest personal tax burden in the country, and Florida has the eighth lowest. Shrum also points to eight states that have targeted wealthy households with extra-high tax brackets: California, New York, New Jersey, Maryland, Hawaii, Oregon, Connecticut and Wisconsin. Six of the top 10 counties the rich are fleeing are located in those states.

In corporate governance, the right people count more than the right structure

On the one-year anniversary of the GM Bankruptcy an article in the Wall Street Journal draws 3 lessons.  We agree with the author that these “might sound blindingly obvious, but it’s amazing how frequently they’re ignored,” and believe a good venture partner helps address such issues through joint ownership and alignment of interests.

1. Problems denied and solutions delayed will result in a painful and costly day of reckoning.
2. In corporate governance, the right people count more than the right structure.
3. Appearances can be deceiving.

The second lesson – on good governance – is one we’ve made before: systems and best practices are important but members’ informal modi operandi determine whether or not all those well-designed systems function properly.  How this applies to the specific example of GM and Ford:

On paper General Motors was a model of good corporate governance, while Ford was (and is) a disaster. The Ford family’s super-voting Class B shares give it 40% of the votes with less than 4% of the shareholder equity. Class B shares get about 31 votes for every share of the Class A stock that nonfamily members own. And the Ford family gets veto power over any corporate merger or dissolution. This structure seems to fly in the face of what is generally understood to be sound principles of good corporate governance. Such “undemocratic” provisions are sure to be lamented this month at two major corporate-governance conferences: the ODX (Outstanding Directors Exchange) in New York, and the annual confab at the Millstein Center for Corporate Governance at Yale. But the Ford board of directors and family came together in 2006 to seek a new CEO from outside the struggling company, even though that meant family scion Bill Ford Jr. had to relinquish command. He volunteered to do so and remains chairman, but not CEO. Meanwhile, the GM board, consisting of blue-chip outside directors who chose a “lead director” from their ranks, steadfastly backed an ineffective management from one disaster to another and wrung its collective hands while the company ran out of cash. Some GM retirees dubbed the directors the “board of bystanders.”

Ford’s governance may not look good on paper, but at least they found the wherewithal to do what had to be done – this time. The next time – and there is always a next time in the up & down that is the business cycle – they’d be better served by better practices. But that is an easier problem to fix than GM’s, which has more to do with getting the team to deal more frankly and forthrightly with the issues at hand and each other.

When business promotes honesty

In this article from The Independent Institute, Dwight R. Lee argues that businessmen are more honest (or less dishonest) in their dealings than preachers, politicians, and professors:

Jean-Leon Gerôme: "Diogenes, Having Failed in his Search for an Honest Man, Finds Some Stoic Dogs"

Jean-Leon Gerôme: “Diogenes, Having Failed in his Search for an Honest Man, Finds Some Stoic Dogs”

Notwithstanding regular reports of dishonest businessmen in the daily news, businessmen deserve more respect for their honesty than they receive.  Granted, businessmen are not always as honest as we would like them to be, and some of them are simply crooked.  The business community would certainly be a strange place for Diogenes to search for a completely honest man.  But would his search prove more successful elsewhere?  In considering the honesty of businessmen in our imperfect world, the relevant question is, compared to whom?  My case for businessmen’s relative honesty is not that they are more virtuous than preachers, politicians, and professors.  Instead, the argument is based on the constraints on those under consideration who might seek to profit from dishonesty.

In our experience, the business case for honesty (the moral case is another discussion) can often be based on the fact that many businesses rely on repeat business.  So although dishonesty may improve the profit or advantage in a single transaction it would result in less success over the long term.

Will Harrell, founding partner of Capco Asset Management in Tampa, has guest blogged for us before (on the subject of inflation), and we found this to be another thought-provoking subject on which to ask him to opine:

This is a terrific issue, and one I agree with in general although perhaps not across-the-board.  The upside from being perceived as a reliable, consistent, trustworthy, &etc. vendor of certain kinds of goods and services is simply huge.  Costco’s CEO has a line I love: “No easy hits on the customer.”  Honesty is just a sub-category of this thesis, which in many cases has more to do with product quality or user experience than honesty per se:  McDonald’s consistency, the taste of a Hershey bar, etc.  It’s also not limited to customers – similar considerations apply to suppliers, capital sources, and employees.

We once wrote on this subject in a quarterly letter, On Being a Good Partner: “But however great or small a company’s advantages, it is our observation that their durability is usually directly related to how good a partner the company is to those with whom it does business.”

It may strike some as corny and simple, yet is exactly what game theory predicts will transpire between participants in repetitive transactions.  What’s surprising is that the effect is not more dominant, and that trustworthy players don’t completely squeeze out untrustworthy ones.

It’s harder to explain the successful (for a time) sleazes like Bernie Madoff or ENRON than the good guys.  There ought to be a Darwinian element to it: where trust or consistency matters, the “good” should attract all the business from the “bad.”  Like bad genes, bad practices should be competed away.

However – bad pennies have a habit of always turning up, and in some cases, thriving.  Perhaps the particular transaction is not repetitive enough, like a car or home purchase; or perhaps customers attach insufficient value to character or are buying a credence good, one whose quality they lack the expertise to judge for themselves even after experiencing it.  (Like most professional services, including mine.)  Of course, some customers rely too heavily on price alone:  the repairman who intends to rip you off can rationally charge less than the honest one who intends to actually do the work and needs to price accordingly.

It’s a fascinating question, with huge implications.  It would be a real political plus for capitalism if more people understood it.

We agree with Mr. Harrell (as well as Mr. Lee).  BPV often backs the same entrepreneurs in more than one business, and we view honesty and consistency as critical to sustaining long term relationships for long term growth as opposed to trying to squeeze maximum value from a single transaction.  We also put a premium on transparency, as it’s easier to remember the importance of being honest when everyone involved in a business relationship can observe how decisions are being made.  In fact, we think that the victims of both Madoff and Enron could have avoided a great deal of misery if they had demanded a level of transparency that would have made both of those schemes unworkable.

From “Why Businessmen Are More Honest than Preachers, Politicians, and Professors“:

Businessmen interested in long-run survival are more honest in their professional dealings than are many other groups in society—not because they are more virtuous, but because they face more effective constraints. Their customers can usually detect and avoid deception more easily than can a politician’s constituents, a professor’s students, and a preacher’s congregants.  …It turns out that, because most businesses are profitable only by earning the patronage of returning customers, they have stronger incentives to be truthful than do preachers (“no one can ‘test drive’ a preacher’s most important promise,” Lee observes), politicians (for whom elections are sporadic and often predetermined by gerrymandering and other devices), or professors (whose customers, the students, “often do not care much about the honesty of the professors’ claims”)…

Yet as long as people continue to embrace beliefs out of comfort or convenience, opportunities will exist for someone to profit by making claims that are intentionally misleading – that is, by acting dishonestly.  Such dishonesty will arise in business, religion, politics, and academics, as some practitioners in those areas yield to the temptation to take advantage of the possible profits.  From this observation, I have made three arguments:

1. First, the costs and benefits of determining the accuracy of claims being made differ in the four occupational areas considered.

2. Second, in business the costs of determining honesty are smaller and the benefits greater than in the other three areas.

3. Third, the lower the costs and the greater the benefits of determining honesty, the more restricted are the opportunities to profit from dishonesty – and the less dishonesty will surface.

Base on these arguments, my conclusion is that, as a rule, businessmen are more honest than preachers, politicians, and professors when making claims about their products.

Sending a Message That You Don’t Care

Texting, emailing, or taking cell phone calls during meetings is a pet peeve of many professionals… and yet many professionals are themselves guilty of the same impolite behavior.  Some new research offers an explanation, of sorts, in the form of “the group-preserving functions of dissociating.”  It turns out that our electronic devices are (over-) feeding a human need to, at times, “disconnect,” and in the process undermining both teamwork and good manners.

Christine Pearson, professor of international business at the Thunderbird School of Global Management in Phoenix and a co-author of “The Cost of Bad Behavior,” writes on the subject in the May 16 New York Times:

Still, the illusion that multitasking can aid productivity is powerful. And it’s abetted by the fact that splitting our Texting in mtgsattention between real and virtual worlds can produce a kind of neural intoxication, research shows.

Through our devices, we find a way to disappear without leaving the room. By splitting ourselves off and reaching out electronically, we fill empty interpersonal space and ignite our senses. We can find relief and a fleeting sense of freedom.

Decades ago, the sociologist Barry Schwartz commended the group-preserving functions of dissociating. Everyone, he said, reaches a threshold beyond which working with others is irritating, even unendurable.

Finding a mental escape can help us deal with the problem. But electronic devices have led to a serious overuse of this strategy — to the detriment of everyone.

We tend not to argue with sociologists, so maybe there’s something to this explanation.  But in our experience the “texting/emailing during meetings” is at its core about trying to multi-task in a world where everyone is busy and being bombarded with messages throughout the day.  The problem is that, while there is no rudeness intended, it is often perceived that way and understandably so.  It’s just hard to claim you value relationships and then not have the courtesy to really focus on what the other person is saying.  Moreover, the preponderance of research shows true multi-tasking is a myth – you really can’t concentrate on more than one thing at the same time.  So we try to turn off the devices during meetings, both internally and with entrepreneurs, and give our full attention to the matters being discussed.  And though we don’t often complain when others do it to us, it does bother us.  So we’ll do our part to hold the emails and calls for after the meeting and hope that others will do the same.

British Petroleum and epic failure

The Deepwater Horizon cataclysm has received the type of “flood the zone” coverage that would mortally damage any brand, but especially the brand of an oil company that had invested heavily in marketing itself as a green company.  (You Know You’re in Trouble When… an online competition to revise your logo emerges spontaneously.)

Even after discounting for the degree of difficulty involved in deep water drilling, and knowing that accidents – even terrible accidents – will happen, we remain flabbergasted that a major corporation could be so woefully unprepared for the worst-case scenario.

From the saturation coverage we found two articles worth highlighting that offer salient advice to the leaders of our own portfolio companies and all entrepreneurs regarding risk management and the dangers of success.

Professor Michael Roberto, author of Know What You Don’t Know, offers seven potential causes of the Deepwater Horizon disaster based on his research into catastrophic failures.  (You can find his book in the  Library at St. Pete.)  Two of them speak directly to (not) preparing for worst-case scenarios:

  • Organizations often overestimate how well the human and system redundancies they have in place will protect them from catastrophe.
  • People often underestimate the probability of what they perceive to be extremely low probability events.

Robert J. Samuelson echoes Professor Roberto in Duped by Success, from the June 7 Washington Post:

The post-crisis investigations will presumably fill out the story. [The precise details of the cause(s) of the failure. – ed]  But they may miss the larger question of why.

No one has yet suggested that the blowout reflected a previously unknown geological phenomenon — something in the oil formation — or a quirk of technology that no one could have anticipated. Perhaps studies will reveal one or the other. But the prevailing assumption is that this accident was preventable, meaning that human error was responsible.  There’s a cycle to our calamities or, at any rate, some of them. Success tends to breed carelessness and complacency. People take more risks because they don’t think they’re taking risks. The regulated and the regulators often react similarly because they’ve shared similar experiences. The financial crisis didn’t occur so much because regulation was absent (many major financial institutions were regulated) but because regulators didn’t grasp the dangers. They, too, were conditioned by belief in the Great Moderation and lower financial volatility.

It is human nature to celebrate success by relaxing. The challenge we face is how to acknowledge this urge without being duped by it.

On BPV’s Youtube channel:
See Professor Roberto discuss his book here, and an animation of the spill’s potential long-term effects  here.

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